RT Journal Article
SR Electronic
T1 The influence of heredity on the persistence and onset-age of asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2990
VO 44
IS Suppl 58
A1 Elina M.S. Paaso
A1 Maritta S. Jaakkola
A1 Aino K. Rantala
A1 Timo T. Hugg
A1 Jouni J.K. Jaakkola
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2990.abstract
AB Background: Parental asthma has been linked to personal asthma previously, but the effects of heredity on the persistence and onset-age of asthma until young adulthood need further studies.Objectives: We investigated the influence of heredity on transient vs. persistent and early-onset vs. late-onset asthma in the Espoo Cohort Study 20-year follow-up of 1623 people (63.2% of the baseline).Methods: Asthmatics (n = 220) were divided into persistent asthma according to symptoms and/or medication in the follow-ups after the initial diagnosis of asthma and transient if otherwise. Persistent asthma was divided into early- and late-onset asthma using the age of 13 years as cut-point. The determinants were any heredity (any parent or sibling); maternal; paternal; both parents; siblings only; parents only and both siblings and parents. Adjusted risk ratios (RRa) were calculated with Poisson regression and Q-statistics to calculate heterogeneity between RRs.Results: Heredity influenced all the subtypes but in various ways. Most hereditary determinants had a stronger impact on persistent asthma than transient, but siblings only had a similar impact on both (persistent: RRa = 2.16, 95% CI = 1.27-3.68; transient: RRa = 2.10, 95% CI = 1.15-3.86; heterogeneity P = 0.95). Maternal asthma seemed to effect only early-onset asthma (RRa = 2.75, 95% CI = 1.62-4.69) while the impact of paternal asthma continued (early: RRa = 2.28, 95% CI = 1.15-4.53; late: RRa = 1.98, 95% CI = 0.76-5.15; heterogeneity P = 0.81).Conclusions: Heredity plays the most important role in persistent and early-onset asthma. The impact of paternal asthma continues to young adulthood while the influence of maternal asthma decreases with age.