PT  - JOURNAL ARTICLE
AU  - Chantal Raherison
AU  - Sylvie Pommiers
AU  - Emeline Scherer
AU  - Gabriel Reboux
AU  - Benedicte Leynaert
AU  - Marie-Christine Delmas
AU  - Christophe Marguet
AU  - Laurence Millon
AU  - Marie-Noelle Dufourg
AU  - Corinne Bois
AU  - Marie-aline Charles
TI  - Late-breaking abstract: Respiratory symptoms and perinatal factors in French new-born children: Results from the ELFE cohort
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P4217
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P4217.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P4217.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background: Many exposures and behavioral patterns during prenatal, perinatal and postnatal period had been studied regarding development of asthma and respiratory health.We aimed to determine the relation between prenatal, perinatal and postnatal outcomes and respiratory symptoms at two months of birth, in a large representative cohort in France.Methods In 2011, the ELFE cohort included n=16030 newborns, ELFE cohort is the first national population-based conducted in France. Using a logistic regression, we examined the association between prenatal, perinatal and postnatal outcomes and wheezing in babies at two months of life.Results: Prevalence of wheezing was 6.5%, significantly more frequent in boys (7.3%) than in girls (5.5%). Prevalence of cough was 25.4 %. Prevalence of bronchitis was 34.6%.Regarding prenatal outcomes: smoking during pregnancy, low socio-economic class, overweight's mother and maternal asthma were significantly associated with wheezing in babies. Regarding perinatal outcomes: maternal diabetes, Apgar score (<7), being a boy were significantly associated with wheezing in babies. For post-natal outcomes: low weight-catch-up, bronchiolitis, reflux, milk allergy, were significantly associated with earlier wheezing. In this national population-based cohort of newborn, a high prevalence of respiratory symptoms was found at two months of birth, with significant associations between prenatal, perinatal and post-natal outcomes and wheezing. Follow-up of these babies until 18 years old will provide useful information regarding respiratory phenotypes.Fundings : INSERM-INED.