RT Journal Article
SR Electronic
T1 Usefulness of serum glycopeptidolipid core immunoglobulin A antibody in mycobacterium avium complex infection
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2589
VO 44
IS Suppl 58
A1 Naohiko Hamaguchi
A1 Mayuko Senba
A1 Koutaro Kajiwara
A1 Kensaku Ito
A1 Naoko Miura
A1 Hideki Makino
A1 Takanori Kanematsu
A1 Hideki Yokoyama
A1 Naohiko Hamaguchi
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2589.abstract
AB [Background] Diagnosis of Mycobacterium avium complex pulmonary disease (MAC-PD) can be difficult. Recently, It has been reported that serum glycopeptidolipid core immunoglobulin A (GPL-core IgA) antibody is useful in MAC-PD[Objective] The aim of this study was to evaluate the usefulness of serodaignostic test in MAC-PD patients and the correlation between the serum GPL-core IgA levels and computed tomography (CT) findings.[Methods] From April 2013 to June 2013,191 patients with known or suspected MAC-PD were enrolled into this retrospective study at Matsuyama Red Cross Hospital, Ehime, JAPAN. CT was made in all patients.MAC-PD diagnosis is made on the basis of American Thoracic Society criteria.[Results] The patients were divided into two groups based on clinical evaluation:28 patients with MAC-PD and 108 who did not meet the criteria. The sensitivity and specificity (cut-off point 0.7 U/mL) of the serodiagnostic test for MAC-PD were 53.6% and 85.2%, respectively.There was not a correlation between the extent of disease and the levels of antibody(r=0.182).[Conclusion] In our study, The sensitivity of GPL-core IgA antibody in MAC-PD patients was poorer than previous study.