RT Journal Article
SR Electronic
T1 Impact of hemodialysis on dyspnea and lung function in end stage kidney disease patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4273
VO 44
IS Suppl 58
A1 Anastasios Palamidas
A1 Sofia-Antiopi Gennimata
A1 Foteini Karakontaki
A1 Georgios Kaltsakas
A1 Ioannis Papantoniou
A1 Antonia Koutsoukou
A1 Joseph Milic-Emili
A1 Demetrios Vlahakos
A1 Nikolaos Koulouris
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P4273.abstract
AB Background: Symptoms defining quality of life and therapy compliance are of major interest in chronic kidney disease patients undergoing maintenance hemodialysis. To the best of our knowledge respiratory symptoms are usually underestimated or overlooked. Therefore, we set out to investigate the prevalence of patients chronic dyspnea, and the relationship of the symptom to lung function indices.Methods: Twenty five clinically stable hemodialysis patients without acute lung disease were included. The modified MRC dyspnea scale was applied to all patients before and immediately after hemodialysis. Common spirometry, single breath nitrogen test, arterial blood gases, static maximum inspiratory (Pimax) and expiratory (Pemax) muscle pressures, and mouth occlusion pressure (P0.1) were also measured pre and post hemodialysis.Results: Despite normal spirometry all patients (100%) reported mild to moderate degree of chronic dyspnea before which was reduced (p<0.001) after hemodialysis. The sole predictor of (Δ) mMRC was the (Δ) P0.1 (r = 0.71, p < 0.001). Static maximum inspiratory muscle strength was reduced before and correlated to the duration of hemodialysis (r = 0.614, p<0.001), whilst after the session was significantly increased (p<0.001). Finally (Δ) weight was correlated with the (Δ) Pimax % pred (r = 0.533, p = 0,006).Conclusion: We conclude that dyspnea is the major symptom among the CKD patients that improves after hemodialysis. The neuro-mechanical dissociation observed probably is one of the major pathophysiologic mechanisms of dyspnea.