PT  - JOURNAL ARTICLE
AU  - Tetyana Kireeva
AU  - Tetyana Pertseva
AU  - Kseniia Bielosludtseva
TI  - Survival predictors of severe community-acquired pneumonia (CAP): Multivariate analysis of immunological and inflammatory parameters
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P2559
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P2559.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P2559.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Aim: to determine the significance of immunological (CD4, CD8) and inflammatory (procalcitonin (PCT)) markers as predictors of survival in patients with severe CAP.Methods: 51 patients with verified severe CAP without HIV (age – 57,50±4,31 years, men – 37 (72,5%), women – 14 (27,5%)). General analysis, determination of serum PCT, blood CD4, CD8 prior antibacterial treatment (ABT) (visit 1), on 8–10 day of ABT (visit 2), cluster analysis.Results: in 6 (11,7%) patients with severe CAP, despite adequate ABT, lethal end of disease was determined. All patients were divided into 3 classes: 1) whose PCT at visit 2 decreased by more than 95,6% and CD4 increased significantly (by more than 335,7%) we can predict recovery with a maximal probability; 2) patients whose PCT at visit 2 decreased by more than 95,3% and CD4 increased by more than 4,7%, have a chance to recover, although the risk of death and pulmonary complications is high; 3) patients whose PCT decreased very slightly (by 1%) or significantly increased (by more than 11,460%) and CD4 decreased by more than 50% have a maximum risk of death.Conclusions: with a substantial decrease of PCT and increase of CD4 during the adequate ABT a favorable outcome of severe CAP can expect, whereas at the increasing of PCT and decreasing of CD4 the survival is unfavorable.