PT  - JOURNAL ARTICLE
AU  - Ramazan Ünver
AU  - Figen Deveci
AU  - Gamze Kirkil
AU  - Dilara Kaman
TI  - Serum heat shock protein levels in patients with chronic obstructive pulmonary disease
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3656
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3656.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3656.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - The aim of this study was determining the level of heat shock proteins (HSPs) secreted by various stress conditions and the relationship of HSPs with various parameters (inflammatory, oxidative, functional status, quality of life) in COPD.The levels of stress protein (HSP27, HSP70, HSP60, HSP90, CyPA), interleukin-6, C-reactive protein and malondialdehyde were measured in 16 healthy non-smoker (Group I), 14 smokers without COPD (Group II) and 50 patients with stable COPD (Group III). Body mass index, pulmonary function tests and arterial blood gases parameters were measured. Health Related Quality of Life was assessed using the St. George's Respiratory Questionnaire and exercise capacity was assessed with 6 minute walking test (6mwt).Only HSP27 levels was significantly higher in group III when compared with both group I and group II (for both, p<0.001). There was a weak to moderate negative correlation between serum levels of HSP27 and PFT parameters (r= -0.428 for FEV1, r= -0.389 for FVC and r= -0.383 for FEV1/FVC, p<0.01 for all) and between HSP27 levels and PaO2 (r= -367, p<0.01). Only weak to moderate positive correlation were found between serum levels of HSP60 and IL-6 levels (r= 0.327, p<0.05). Serum levels of HSP27 showed a weak to moderate positive correlation with symptom, activity and total scores (r= 0.351 for symptom, r= 0.294 for activity, r= 0.316 for total score, p<0.05 for all).Increased HSP27 levels in COPD patients suggest that HSP27 may have a potential role in the pathogenesis of COPD associated with hypoxia. In addition, HSP27 may be an indicator associated with patient's functional status, quality of life and duration of disease.