PT  - JOURNAL ARTICLE
AU  - Regina Hasa
AU  - Hasan Hafizi
AU  - Dafina Todri
AU  - Roland Hasa
AU  - Eritjan Tashi
AU  - Sofiela Telo
TI  - Chronic obstructive pulmonary disease (COPD) and alterations of hemogram
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3988
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3988.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3988.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background: The aim of this study was to determine the values of hematological markers and some other biomarkers in patients with stable COPD in order to define the presence of anemia,degree of systemic inflammation and correlations between the analytes.Methods: We evaluated CBC, biochemical, bloodgas and spirometry studies performed in 87 COPD patients (FEV1 = 50 ± 5.75%) and 17 control subjects (FEV1 = 103 ± 10%). Pursuant to GOLD guidelines, the patients were divided into 4 subgroups and for hematology, into 3 subgroups: subjects with anemia, without anemia and those with slight polyglobulia.Mean age resulted 65.7(38-84). 68.3% of cases were smokers.27% of patients had cardiac diseases,16.3% were hypertensive subjects ,11.5% had secondary infections, 8% renal disease and 6% with DM typeII.Results: No significant differences were found in the values of RBC,HBG and Htc either between the group of all COPD patients and control subjects or between GOLD subgroups and control subjects.Anemia was present in 8% of the COPD cases ,mostly subjects with renal disease and secondary infection.Polyglobulia was mostly present in Stage III- IV COPD patients >70 years(28.7%). ES revealed good negative correlation with RBC, Hb and Htc (r= -0.7, r= -0.673,r= -0.679 respectively;p<0.001each).Fibrinogen revealed good significant negative correlations with RBC,FEV1 and pO2(r=-0.217,p=0.027;r=-0.220,p=0.025 and r=-0.265,p=0.012 respectively).We found a good negative correlation between WBC and pO2 (r= -0.213, p< 0.05).Neutrophilia revealed good negative correlation with FEV1 r= -0.258,p= 0.01 and pO2 r= -0.401,p=0.001)Conclusion: Inflammation and comorbidities induce hemogram changes in COPD patient. especially in last stages.