%0 Journal Article %A Cláudia Chaves Loureiro %A Pedro Sá Couto %A Ana Todo-Bom %T Asthma clusters in a real asthmatic population, treated in secondary medical care %D 2014 %J European Respiratory Journal %P P4044 %V 44 %N Suppl 58 %X Background: Due to asthma heterogeneity new analyses strategies were developed in order to group patients, namely by cluster approach, leading to the emergency of new endotypes distinguished by the extension of Th2 response. Our study intended to cluster a real asthmatic population, treated in secondary medical care, including severe asthmatic patients, to better understand the underlying mechanism of this disease.Methods: Patients with asthma were recruited from outpatient clinic. SPSS ® Software, version 20.0 (SPSS, Inc., Chicago, IL) was used for cluster and inferential analyses, in a non-supervised way. Chosen variables included demographic data; comorbidities; disease control, quality of life and risk assessment; lung function; blood biomarkers.Results: 57 elements were included and distributed in 5 clusters (C). C1 (n=7): more severe patients with late asthma onset, fixed airway obstruction, being frequent smoke exposure and AINE´s hypersensitivity; C2 (n=19): obese female asthmatics, highly symptomatic with late disease onset; C3 (n=10): brittle asthma phenotype, in young allergic females with early disease onset; C4 (n=15): older females with moderate allergic asthma and long disease evolution; C5 (n=6): eosinophilic mild allergic asthma, early disease onset.Conclusions: Distribution was set in 5 clusters, overlapping with findings from other studies. Adapting our results to known plausable endotypes, C5 can be associated with Th2 response; C2 with non-Th2 response; C1 and C4 with mixed response (the first conditioned by smoke exposure and AINE´s hypersensitivity and the second by weight gain). Finally, C3 might be associated with mixed response, with Th2 prevalence. %U