TY - JOUR T1 - The role of amino-terminal pro-brain natriuretic peptide (NT-proBNP in clinical evaluation of patient with acute exacerbation chronic obstructive pulmonary disease JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2070 AU - Lamia Shaaban AU - Amany Mohamed AU - Hanan Mohamed Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2070.abstract N2 - COPD is a progressive disease, often associated with chronic co morbidities, leading to a significant burden for the patient. Aim of the work:toassess plasma NT-proBNP level in patients with acute exacerbation of COPD (AECOPD) and to evaluate the prognostic value of elevated NT-proBNP levels to predict in-hospital outcome of those patients. Material and Methods: From 1 November 2010 to 30 April 2011, 45 adult patients ≥ 40 years of age with acute exacerbation of COPD (AECOPD) admitted to department of pulmonary medicine &or Respiratory ICU ;Assiut University Hospital; Egypt were enrolled in this study. Plasma NT-proBNP levels were measured and systolic pulmonary arterial pressure (SPAP) was estimated by echocardiography.Results: NT-proBNP levels were significantly elevated during the acute exacerbation compared to recovery (254 pg/mL vs 89 pg/mL ; p = 0.000). Also in those patients requiring ICU admission [416 pg/mL ] vs [200.5 pg/mL ]p=0.000.To predict ICU admission in AECOPD, ROC analysis was performed with NT-proBNP level > 300 has the best sensitivity and specificity (Sensitivity = 89.5%, Specificity = 92.3%) with area under the ROC curve (AUC) = 0.933.NT-proBNP levels at exacerbation were significantly elevated in patients with cor pulmonale compared to those without cor pulmonale [329 pg/mL ] vs [197pg/mL ]p=0.000. With cut-off level of NT-proBNP > 214 pg/ml, which gives the best sensitivity and specificity (Sensitivity = 95.7%, Specificity = 72.7%) with AUC = 0.895.Conclusions: plasma NT-proBNP levels are elevated in AECOPD patients and can predict the need for ICU admission. ER -