RT Journal Article
SR Electronic
T1 Performance of utility instruments in evaluating response to CPAP in patients with obstructive sleep apnea
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2019
VO 44
IS Suppl 58
A1 Fabienne L. Huber
A1 Tsogyal D. Latshang
A1 Malcolm Kohler
A1 Yvonne Nussbaumer-Ochsner
A1 Otto D. Schoch
A1 Irene Laube
A1 Edelbert Imhof
A1 Alexander J. Turk
A1 Robert Thurnheer
A1 Oliver Senn
A1 Konrad E. Bloch
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2019.abstract
AB Introduction: In patients with obstructive sleep apnea syndrome (OSAS), evaluation of subjective health preference (utility) is not well established although it is essential for cost-effectiveness analysis. Therefore, we compared the response of several utility instruments to continuous positive airway pressure (CPAP) therapy in patients with OSAS. Methods: 172 OSAS patients underwent evaluation of utility by several instruments and sleep studies before initiation of CPAP therapy and after 2 years. Mean changes and effect sizes (ES=change/SD of mean baseline value) were computed. Results: After 2y of CPAP the apnea/hypopnea index (AHI) was in the normal range. The changes in utility measured by different instruments varied largely.View this table:Effect of 2y of CPAPConclusion: In OSAS patients different utility instruments used in cost-effectiveness analyses reveal large differences in responsiveness to CPAP. The SF-6D and the visual analog scale (Euro-thermometer) had moderate effect sizes, the standard gamble and EQ-5D instruments were non-responsive to CPAP. Grants: SwissNationalFoundation, LungeZürich, Lungenliga St.Gallen, ResMed, PhilipsRespironics.