PT - JOURNAL ARTICLE AU - Tamara Alonso AU - Rosa Mar Gómez-Punter AU - Emma Vázquez AU - Cristina López AU - Elena García AU - Rosa María Girón AU - Julio Ancochea TI - COPD and <em>pseudomonas aeruginosa</em>, an association DP - 2014 Sep 01 TA - European Respiratory Journal PG - P2544 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P2544.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P2544.full SO - Eur Respir J2014 Sep 01; 44 AB - Introduction: Isolation of Pseudomonas aeruginosa (PA) in patients with COPD seems to be a marker of poor prognosis as it is related to a greater number and severity of exacerbations, increased airflow obstruction and lower BODE index.Objective: Describe the main characteristics of our patients with moderate-severe COPD and single or repeated isolation of PA.Methods: Observational, retrospective study. 20 patients. Analyzing sex, age, body mass index (BMI), Charlson index, dyspnea on the Medical Research Council (MRC) scale, phenotype according to the Spanish Guideline (GesEPOC), airflow obstruccion, bronchiectasis on High Resolution Computed Tomography (HRCT), number of exacerbations, antibiotic treatment and the BODE and BODEx scales in the previous and the posterior year after treatment.Results: 90% male; mean age of 73.95 years (SD±9.88), BMI of 19.8, Charlson index 3.40 (SD 1.75). 50% had grade 3 dyspnea of MRC. According to the GesEPOC, 65% phenotype D, 20% phenotype C and 10% phenotype B. 95% of patients presented bronchiestasis. 70% of them had a single isolation and 30% repeated. Antibiotic treatment is shown in . Exacerbations pre and post treatment were 3.4 (SD±2.13) and 1.7 (SD±1.5) respectively (p&lt; 0.0001). BODEx index decreased from 5.2 to 4.27 (p &lt;0.038).Conclusions: PA isolation is associated with increased number and severity of exacerbations. Anti-pseudomonal treatment reduces respiratory exacerbations with better prognosis.