RT Journal Article SR Electronic T1 Comparison of yield of acid fast bacilli (AFB) from induced sputum versus gastric lavage for diagnosis of pulmonary tuberculosis in children JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2670 VO 44 IS Suppl 58 A1 Kamal Kumar Singhal A1 Gulshan R. Sethi A1 M. Hanif YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P2670.abstract AB Comparison of yield of Acid Fast Bacilli (AFB) from induced sputum versus gastric lavage for diagnosis of pulmonary tuberculosis in children.Authors: Kamal Kumar Singhal, G. R. Sethi, M HanifIntroduction: In the absence of adequate specimen the diagnosis of pulmonary tuberculosis(PTB) in infants and young children is usually difficult. Scant reports have compared IS with GL. Aims : 1) Comparison of diagnostic yield of mycobacterium tuberculosis from repeated samples of IS versus repeated samples of GL, in children with suspected PTB .2) Safety and acceptability of sputum induction. Study Subjects: Patients of suspected PTB aged 1 month to 12 years. Inclusion criteria: Fever or persistent cough or both for more than 2 weeks, loss of weight or no weight gain, history of contact with suspected or diagnosed case of active TB. Exclusion criteria: Taking prophylaxis for tuberculosis or Arterial oxygen saturation < 92 % on room air. Outcome Variables: Primary outcome variable was comparative yield of Mycobacterium tuberculosis from two techniques and secondary outcome variable were adverse events. Results: A total of 176 samples (2 GL and 2 IS from each patient) were sent from these 44 patients. Out of these 7 (15.9%) were detected as PTB. The smear positivity rate from IS and GL were 12.5% and 7.95 % respectively. Good agreement (kappa=0.63, p<0.000) was found on applying Kappa statistics. The culture positivity rate from IS and GL were 3.4 % and 0 % respectively. Conclusions: The smear positivity and culture positivity of induced sputum sample is more than gastric lavage in children with suspected PTB.