TY - JOUR T1 - Impact of diabetes mellitus on clinical parameters and treatment outcomes of diagnosed pulmonary tuberculosis patients JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2662 AU - Jihen Ben Amar AU - Bouthaina Ben Safta AU - Besma Dhahri AU - Saloua Azzabi AU - Mohamed Ali Baccar AU - Hichem Aouina AU - Hend Bouacha Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2662.abstract N2 - Tuberculosis (TB) is an infectious disease which is still a major cause of morbidity and mortality throughout the world. People with diabetes have a three times higher risk of developing active TB than people without diabetes.Aim: The aim of this study is to determine the impact of diabetes on clinical and radiological manifestations and treatment outcome of pulmonary TB (PTB) patients.Methods: We have retrospectively analyzed clinical features in 30 diabetic patients treated for TB; this group was compared to a control group of 65 non-diabetic tuberculosis patients.Results: In the diabetic group, the mean age is 52 years (22-74); 52% of patients had type I diabetes. The duration of diabetes course at the time of PTB diagnosis varied from 1 month to 16 years. The most frequent symptom was weight loss found in 85% of cases. Haemoptysis was noted in 50% and fever in 61% of patients. Radiographic abnormalities were bilateral in 74 % of patients; lower lung lesion was observed in 52% of patients. The percentage of patients with cavities was higher in the patients with diabetes (74%) than in those without (38%; P< 0.05).The diagnosis of PTB was made by microscopic sputum examination and sputum culture in all patients. Five patients had extrapulmonary TB: liver (2 cases), blood (2 cases) and bone in one case.Therapy length is similar between two groups. No drug resistance was noted. Insulin was required in all patients with type II diabetes. Diabetes is associated with a higher frequency of lung after-effects compared with non-diabetic (52% vs 20%; p<0.05).Conclusion: PT seems to aggravate diabetes course and diabetes seems to increase radiological after-effects. ER -