TY - JOUR T1 - Yield of pleural cytology and macroscopic pleural invasion in metastatic pleural effusion JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2774 AU - Jérôme Plojoux AU - Marios Froudarakis AU - Elise Kaspi AU - Sophie Laroumagne AU - Hervé Dutau AU - Philippe Astoul Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2774.abstract N2 - Introduction: Diagnostic sensitivity of pleural fluid (PF) cytology is 40-60% and is related to sample size and cytologist's experience. Pleural extension could be a factor. We assessed PF cytology yield in relation to pleural invasion.Method: Medical records of 288 patients were reviewed. PF cytology, reported appearance during thoracoscopy and malignant diagnosis were inclusion criteria. Mesothelioma was excluded.Results: NSCLC and breast cancer were most frequent etiologiesView this table:Final diagnosis. 56% of patients had positive PF cytology. Thoracoscopy reported parietal pleural invasion in 97% of subjects. 81% of patients with positive cytology had visceral pleural invasion, while only 30% of those with negative cytology.Conclusion: PF cytological yield is significantly higher in patients with visceral pleural invasion. Positive PF cytology might be associated with more advanced disease. ER -