TY - JOUR T1 - Clinical characteristics and prognosis of chronic pulmonary aspergillosis JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2583 AU - Jusang Kim AU - Joonghyun Ahn AU - Ahyoung Shin AU - Hwayoung Lee AU - Soonseok Kwon AU - Chihong Kim AU - Sunkyung Kim Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2583.abstract N2 - Background : This study investigated the clinical features and progrnosis of of Chronic cavitary pulmonary aspe rgillosis (CCPA) Methods : we reviewed the medial records of the patients with positive serum Aspergilus IgG or Aspergillus Ag or Aspergillus species isolated from respiratory specimens. Results :A total of 35 patients with suspected pulmonary aspergillosis were identified,(4 ABPA, 3 CNPA, 8 IPA, 5 simple aspergilloma and 15 CCPA). 15 patients were males, median age of 57 years. 63.6% (n=7) of the patients were ever smokers. Old pulmonary tuberculosis (n=15) and emphysema (n=4) were primary underlying lung conditions. Most frequent symptom was hemoptysis, 42.9% (n=6). Comparing the asymptomatic simple aspergilloma, larger cavity size, pleural thickening, bronchiectasis, and BPF was more frequently found in chest computed tomography of CCPA. Total 8 patients (57.1%) were treated with itraconazole (100%), amphotericin B deoxycholate (12.5%) and voriconazole (37.5%) for mean 134 days and 2 had curative operations. For median 206 days follow up periods, 66.7% (n=6) had favorable responses in symptoms (44.4%) or radiologic findings (55.5%). During the treatment, serum Aspergillus IgG titer was decreased in patients with favorable responses (33.3%), whereas none with unfavorable responses or without the antifungal treatment.Conclusions :Previous pulmonary tuberculosis infection and emphysema could be the risk factors for CCPA development. We suggest that patients with simple aspergilloma who present progressive symptoms with radiological changes and high serum Aspergillus IgG titer should be considered to use antifungal agents, anticipating favorable clinical outcomes. ER -