PT  - JOURNAL ARTICLE
AU  - Maria Wilczynska
AU  - Keir E. Lewis
AU  - P. Rhodri Williams
AU  - Sophie Stanford
AU  - Matthew Lawrence
AU  - Phillip A. Evans
TI  - Obstructive sleep apnoea is associated with the increased prothrombotic state
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P1535
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P1535.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P1535.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Introduction: Obstructive sleep apnoea (OSA) appears to be an independent factor for arterial and venous thrombosis. Fibrinogen (FBG) and thrombin interactions result in the fibrin clot formation. In a healthy state excessive thrombosis is limited by the activation of fibrinolytic pathway of which tissue plasminogen activator/plasminogen activator inhibitor-1 (TPA/PAI-1) complex is a marker. The aim of this study was to compare morning and afternoon levels of thrombin generation (TG), FBG and TPA/PAI-1 complex in controls and subjects with a newly diagnosed OSA.Methods: Nineteen patients with newly diagnosed moderate/severe OSA and ten controls with similar symptoms but negative sleep studie were enrolled. Whole blood was collected at 4pm and after sleep the following morning. Tests were performed using the TG Assay (Technoclone Diagnostics, Vienna, Austria), Zymutest TPA/PAI-1 complex assay (Hyphen Biomed, Epsom, UK) and Clauss Fibrinogen assay (Sysmex, Kyoto, Japan).Results: There were no significant differences in the measured haemostatic factors levels within and between groups (all p>0.05).View this table:Haemostatic factors in OSAHS and controls. Results are presented as mean and SD.Conclusions: Despite lack of significant differences in haemostatic markers levels between and within groups, there was a trend for a higher TG levels in the OSA indicating increased prothrombotic predisposition. Furthermore we observed increased levels of TPA/PAI-1 complex in both groups reflecting impaired fibrinolysis.