RT Journal Article
SR Electronic
T1 Analysis of circadian blood pressure rhythms and cardiovascular risk factors in patients with hypertension and sleep apnea syndrome
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2248
VO 44
IS Suppl 58
A1 Enrique Javier Soto Hurtado
A1 Ester Marín Gámez
A1 Maria Jesús Gutierrez Fernández
A1 Francisco José Cabello Rueda
A1 Jose Maria Ignacio Garcia
A1 Jose María García Jiménez
A1 Alberto Ruíz Cantero
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2248.abstract
AB Objectives: Assess the impact of non-dipper profile of blood pressure on cardiovascular risk of hypertensive patients with obstructive sleep apnea-hypopnea syndrome (OSAS).Methods: We studied 100 hypertensive patients with OSAS. Patients answered a questionnaire on cardiovascular health and were determined anthropometric measurements, office blood pressure , 24-hour ambulatory blood pressure monitoring (ABPM), complete blood test and echocardiography of supra-aortic trunks. Statistical analysis performed using SPSS version 17.Results: Of the total, 52 were diagnosed as non-dipper. We observed no differences in biochemical parameters and prevalence of metabolic risk factors among non-dipper and dipper. 78.8% of the non-dipper were obese, and 75% of dippers. Non-dipper patients had higher nocturnal BP (106 vs. 96mmHg) and pulse pressure (59.3 vs. 55mmHg ). Regarding office blood pressure, 21.2% of non-dippers had severe hypertension compared to 16 % of dippers. Sleep parameters (non-dipper/dipper): apnea-hypopnea index: 47.9/40.7; total number of apneas and hypopneas: 242/198; arousal index: 52.7/45.5. Severe OSA were 38.5% of non-dippers, compared to 27.1% of dippers. Echocardiography of supra-aortic trunks: presence of atheromatous plaques(44% vs. 32%), intimal thickening (59.4% vs. 44.8%).Conclusions: Although all hypertensive patients with OSAS are at high cardiovascular risk, the presence of a pattern of non-dipper BP further increases the risk. Patients with non-dipper pattern present greater severity in sleep parameters and higher percentage of severe OSAS.