PT  - JOURNAL ARTICLE
AU  - Enrique Javier Soto Hurtado
AU  - Ester Marín Gámez
AU  - Maria Jesús Gutierrez Fernández
AU  - Francisco José Cabello Rueda
AU  - Jose Maria Ignacio Garcia
AU  - Jose María García Jiménez
AU  - Alberto Ruíz Cantero
TI  - Analysis of circadian blood pressure rhythms and cardiovascular risk factors in patients with hypertension and sleep apnea syndrome
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P2248
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P2248.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P2248.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Objectives: Assess the impact of non-dipper profile of blood pressure on cardiovascular risk of hypertensive patients with obstructive sleep apnea-hypopnea syndrome (OSAS).Methods: We studied 100 hypertensive patients with OSAS. Patients answered a questionnaire on cardiovascular health and were determined anthropometric measurements, office blood pressure , 24-hour ambulatory blood pressure monitoring (ABPM), complete blood test and echocardiography of supra-aortic trunks. Statistical analysis performed using SPSS version 17.Results: Of the total, 52 were diagnosed as non-dipper. We observed no differences in biochemical parameters and prevalence of metabolic risk factors among non-dipper and dipper. 78.8% of the non-dipper were obese, and 75% of dippers. Non-dipper patients had higher nocturnal BP (106 vs. 96mmHg) and pulse pressure (59.3 vs. 55mmHg ). Regarding office blood pressure, 21.2% of non-dippers had severe hypertension compared to 16 % of dippers. Sleep parameters (non-dipper/dipper): apnea-hypopnea index: 47.9/40.7; total number of apneas and hypopneas: 242/198; arousal index: 52.7/45.5. Severe OSA were 38.5% of non-dippers, compared to 27.1% of dippers. Echocardiography of supra-aortic trunks: presence of atheromatous plaques(44% vs. 32%), intimal thickening (59.4% vs. 44.8%).Conclusions: Although all hypertensive patients with OSAS are at high cardiovascular risk, the presence of a pattern of non-dipper BP further increases the risk. Patients with non-dipper pattern present greater severity in sleep parameters and higher percentage of severe OSAS.