@article {JungP1215, author = {Andreas Jung and Christina Amaxopoulou and Ralph Gnannt and Robert G{\"o}tti and Christian Bieli and Renate Spinas and Alexander M{\"o}ller and Christian Kellenberger}, title = {Lung MRI findings in children with cystic fibrosis}, volume = {44}, number = {Suppl 58}, elocation-id = {P1215}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Background: In the light of a significantly extended life expectancy, sequential X-ray or CT scans to monitor lung disease in cystic fibrosis (CF) require critical appraisal. Lung MRI has been suggested recently as a surveillance tool in CF adults. Here we demonstrate MRI findings in children with CF.Methods: Lung MRI from 25 clinically stable children with CF (mean age 5y, range 1-20y) was analysed retrospectively. All MRI was performed at 1.5T including T2-weighted respiratory-triggered Propeller FSE and fast dynamic contrast-enhanced imaging (single dose Dotarem, temporal resolution 1 {\textendash} 2s). Any morphologic change was described and perfusion abnormalities assessed qualitatively and by measuring signal enhancement and time to peak.Results: Frequent findings in CF patients were consolidation (22/25, 88\%) including dependant atelectasis (14/25, 56\%), bronchial wall thickening (24/25, 96\%), bronchiectasis (5/25, 20\%), mucus plugging (2/25, 8\%) and prominent mediastinal and tracheobronchial lymph nodes (20/25, 80\%). Perfusion defects of varying degrees were seen in 21/25 patients (84\%), with decreased enhancement and prolonged time to peak. All consolidations demonstrated increased enhancement. Dependant atelectasis showed similar time to peak as normal lung, while more ventrally located consolidations as in lingula or middle lobe showed prolonged time to peak.Conclusion: Lung MRI can demonstrate the typical CF findings in children as described by CT. In addition, dynamic contrast-enhanced imaging reveals lung perfusion abnormalities and may allow differentiation between chronic consolidations and acute atelectasis due to sedation. Thus, lung MRI is a promising tool for the monitoring of lung disease in CF children.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P1215}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }