PT  - JOURNAL ARTICLE
AU  - Cecilia Andersson
AU  - Medya Shikhagaie
AU  - Amal Al-Garawi
AU  - Michiko Mori
AU  - Robert Welliver
AU  - Thais Mauad
AU  - Leif Bjermer
AU  - Manel Jordana
AU  - Jonas Erjefalt
TI  - Mast cells infiltrate the alveolar parenchyma in young children with respiratory viral infections
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - 3225
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/3225.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/3225.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background: Asthma usually develops during childhood and is associated with increased numbers of lung MCs (MCs). Whether viral infections in young children can cause increased MC numbers and contribute to asthma development is unknown. We sought to investigate if lower respiratory tract infections (LRTIs) cause alterations in lung MC populations in children.Methods: Lung tissue from 21 young children who died following LRTIs was processed for immunohistochemical identification of MCs and related mediators. Ten children who died from non-respiratory causes were used as controls. MC changes in relation to sensitization were further examined in infant mice exposed to house dust mite (HDM) during the course of influenza A infection.Results: An increased number of MCs were observed in the alveolar parenchyma of young children infected with LRTIs compared to controls. This was associated with a higher frequency of CD34+ tryptase+ MC progenitors and an increased expression of vascular cell adhesion molecule (VCAM)-1. Similar to children with LRTIs, infant mice infected with influenza A had an increased number of alveolar MCs. MCs numbers continued to increase and remained significantly higher at 6 weeks post infection and allergy challenge.Conclusions: The results from our study demonstrate that a viral infection affecting the peripheral lung evokes a rapid accumulation of MCs in the alveolar parenchyma in both infant humans and mice. Since MCs are very long-lived and are likely to remain in the tissue after the infection has been cleared, a notion supported by the animal data, the increased MC numbers might also affect susceptibility towards allergens and asthma development later in life.