@article {Roskell1905, author = {Neil Roskell and Owain Saunders and Dawn Lee and Mark Fisher}, title = {Long-term survival analysis: Pirfenidone compared to standard care for the treatment of patients with idiopathic pulmonary fibrosis}, volume = {44}, number = {Suppl 58}, elocation-id = {1905}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Objectives: Idiopathic pulmonary fibrosis (IPF) is a rare, fatal lung disease. Pirfenidone is a novel treatment for IPF patients. This analysis sought to predict survival with pirfenidone compared to standard care using clinical trial data and the CPRD-GOLD database.Methods: Pirfenidone patients (2403 mg/day) from the two phase 3 CAPACITY trials, including up to 7-years follow-up from the extension study RECAP, were included in the analyses [n=345]. Standard care patients in the CPRD-GOLD database were identified using IPF-related READ codes and used as a reference group [n=193]. Survival times were recorded from diagnosis with CPRD, and from randomisation with the CAPACITY trials. Therefore, CPRD survival times were adjusted using random-sampling of diagnosis to randomisation collected in the CAPACITY trials. The CPRD cohort was restricted to only include patients with an FVC\>50\%, as per the inclusion criteria of the CAPACITY trials, in an effort to ensure similar levels of impairment in lung function between the two cohorts. Median survival was calculated within each group using the Kaplan-Meier estimator. Mean survival was extrapolated using parametric survival modelling techniques.Results: Median survival was 6.87-years with pirfenidone compared to 3.41-years with standard care. Using stratified Weibull models, mean survival was 9.25-years (95\% CI: 7.37-11.73) with pirfenidone compared to 5.25-years (95\% CI: 4.05-7.00) with standard care.Conclusions: This analysis suggests that for IPF patients treated with pirfenidone, survival is increased relative to patients in standard care, acknowledging the limitations of cross data source comparisons.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/1905}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }