TY - JOUR T1 - Determinants of maximal inspiratory force and handgrip in a population of healthy elderly subjects JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2148 AU - Frédéric Costes AU - Sébastien Celle AU - Martin Garet AU - Michel Kossovsky AU - Jean Claude Barthélémy AU - Frédéric Roche Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2148.abstract N2 - Peripheral muscle strength decreases with aging, affecting up to 50% of >80 years old subjects. The relationship between muscle depletion and a reduced respiratory strength has not been extensively studied. From a cohort of healthy old subjects (the Proof cohort), we compared the determinants of a reduced maximal inspiratory pressure (MIP) and those of a reduced handgrip (HG) as an index of whole body muscle force.We measured MIP, and HG of the dominant arm, in 393 healthy subjects aged 72±1 years old. Body composition (biphotonic absorptiometry) and daily energy expenditure (24h_DEE) questionnaire were determined 3 years before. Fat free mass (FFM) was calculated for whole body and for the trunk and was indexed to height (FFMI).Mean MIP was 77±26 % of predicted value and 90 subjects had a MIP value below normal. Mean HG was 106±19% of predicted value and was reduced below normal in 30 subjects.We found only a weak correlation between MIP%pred and HG%pred (r=0.175, P<0.001).FFMI, the percentage of FFM of the trunk, and 24h_DEE were the only significant covariates which influenced the reduction of MIP. HG reduction was determined by sex, body FFM and 24hDEE.We conclude that the determinants of a reduction of MIP in elderly differed from those of the HG force, suggesting a differential regulation of respiratory muscle force. ER -