RT Journal Article
SR Electronic
T1 Ventilatory efficiency and exercise capacity during exercise in the patients with idiopathic pulmonary fibros
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2167
VO 44
IS Suppl 58
A1 Jinming Liu
A1 Dandan Huang
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2167.abstract
AB OBJECTIVES To study the characteristics of ventilatory efficiency and exercise capacity during Cardiopulmonary Exercise Testing(CPET) in patients with idiopathic pulmonary fibrosis(IPF).METHODS Pulmonary function test, arterial blood gas analysis and cardiopulmonary exercise testing were performed in 28 cases of patients with idiopathic pulmonary fibrosis from April 2012 to April 2013 and 28 cases of healthy volunteers and measured the relevant parameters.RESULTS The parameters from pulmonary Function test such as FVC% predicted,FEV1% predicted,MVV % predicted,TLC% predicted,RV% predicte,and DLCO% predicted in the IPF group were significantly lower than those of the control group.The parameters from arterial blood gas analysis, such as PaO2,SaO2 were lower than those of the control group, thus, P(A-a)O2 in the IPF group was higher than that in the control group. These results strongly suggestted that IPF group existed restrictive ventilatory dysfunction and impaired gas exchange.The IPF patients had higher VE/VCO2-slope(P<0.01)and Lowest VE/VCO2(P<0.01) than the controls; VE/VCO2and VD/VT during every period were significantly higher in IPF group than in the control group(P<0.01);during peak exercise, peakLoad%pred(P<0.01),peakVO2%pred(P=0.001) were significantly lower in IPF group than in the control group.In IPF group,VE/VCO2@AT,VE/VCO2-slope,Lowest VE/VCO2both had a negative correlation with DLCO%pred and VE/VCO2@AT,VE/VCO2-slope,LowestVE/VCO2both had a negative correlation with peakVO2%pred.CONCLUSIONS With CPET,we find that the ventilation efficiency of the IPF patients were significantly reduced and seriously affecting the patients' exercise tolerance.