RT Journal Article
SR Electronic
T1 Exercise-induced pulmonary pressure changes in scleroderma patients – A follow-up study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4842
VO 44
IS Suppl 58
A1 Gabor Kovacs
A1 Alexander Avian
A1 Nora Wutte
A1 Franz Hafner
A1 Florentine Moazerdi-Fürst
A1 Elisabeth Aberer
A1 Marianne Brodmann
A1 Winfried Graninger
A1 Vasile Foris
A1 Maria Tscherner
A1 Xhylsime Kqiku
A1 Andrea Olschewski
A1 Horst Olschewski
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/4842.abstract
AB BackgroundAlthough systemic sclerosis is a risk factor for the development of pulmonary hypertension (PH), the development of PH is not fully understood. Our goal was to follow-up hemodynamic changes at rest and during exercise in patients with systemic sclerosis.Patients and methodsPatients with systemic sclerosis underwent exercise echocardiography, cardiopulmonary exercise testing and part of them right heart catheterization (RHC) at rest and during exercise at baseline and 3-5 years after their first examination. Patients with known relevant cardiac and pulmonary limitations were excluded. Primary end point was systolic pulmonary artery pressure (SPAP) at 50 W. In the subgroup with repeated RHC, primary end point was resting mean pulmonary arterial pressure (mPAP). To compare the results of the baseline and follow-up measurements paired t-tests were used.ResultsN=85 patients were included. SPAP at 50W increased (39.5±11.6 to 42.9±10.1, p<0.05), and peak oxygen uptake decreased (79.4±22.5 to 73.9±21.2, p<0.05) between baseline and follow-up. In the right heart catheterization subgroup n=36 patients were included. Here, mPAP at rest did not change significantly (16.1±3.5 to 17.0±3.4, p=0.16), but mPAP at 50W increased (27.3±5.0 to 29.6±6.6, p<0.05) during follow-up. Manifest PH developed in one patient.ConclusionWe observed a mild, but significant PAP increase during exercise and peak oxygen uptake decrease after 3-5 years follow-up in our scleroderma patients without known relevant cardiac and pulmonary limitations at baseline. Further analysis of the data may reveal parameters to recognize patients with more rapid deterioration.