@article {GessnerP899, author = {Christian Gessner and Stephanie Korn and Wolfgang Sch{\"u}rmann and Karin F{\"o}rster and Christian Sieder and Simone Hiltl and Roland Buhl}, title = {Once-daily QVA149 improves lung function and dyspnoea compared with tiotropium plus formoterol: The QUANTIFY study}, volume = {44}, number = {Suppl 58}, elocation-id = {P899}, year = {2014}, publisher = {European Respiratory Society}, abstract = {IntroductionThe QUANTIFY study compared QVA149, an approved once-daily (OD) LABA (indacaterol) plus LAMA (glycopyrronium) dual bronchodilator combination, with the free-dose combination of tiotropium plus formoterol (TIO+FOR) regarding lung function, dyspnoea and health-related quality of life in patients with COPD.MethodsThis double-blind, triple-dummy 26-week study randomised patients with moderate-to-severe COPD to QVA149 110/50{\textmu}g OD or TIO 18{\textmu}g OD plus FOR 12{\textmu}g b.i.d. (1:1). Endpoints included pre-dose FEV1 and FVC, TDI responder rates and St George{\textquoteright}s Respiratory Questionnaire-COPD (SGRQ-C).ResultsOf the 934 patients randomised (QVA149 [N=476] and TIO+FOR [N=458]) 87.9\% completed the study. Non-inferiority of QVA149 was met with respect to SGRQ-C (least square mean treatment difference [LSMTD] {\textendash}0.69 units, 95\% CI {\textendash}2.31 to 0.92). QVA149 showed statistically significant improvements in lung function (pre-dose FEV1: LSMTD=68 mL, p\<0.001; pre-dose FVC: LSMTD=74 mL, p\<0.01) and TDI responder rates (risk ratio=1.17; p\<0.05) versus TIO+FOR. Similarly, QVA149 significantly improved pre-dose FEV1 irrespective of age, gender, inhaled corticosteroid (ICS) use and COPD severity (Figure 1).ConclusionQVA149 significantly improved lung function as well as dyspnoea and was non-inferior in improving health-related quality of life compared with TIO+FOR free-dose combination.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P899}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }