PT - JOURNAL ARTICLE AU - Antonio Moreno-Galdó AU - Eduardo G. Pérez-Yarza AU - Octavio Ramilo AU - Asunción Mejías TI - Respiratory morbidity in moderate to late preterm infants during the first three years of life: SAREPREM 3235 study DP - 2014 Sep 01 TA - European Respiratory Journal PG - P1251 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P1251.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P1251.full SO - Eur Respir J2014 Sep 01; 44 AB - Objectives. To determine the incidence and risk factors associated with recurrent wheezing (RW) in a Spanish birth cohort of infants born at 32-35 weeks of gestation.Methods. Prospective, longitudinal multicenter study of preterm infants (32-35 w) followed until 3 years of age. Development of physician-diagnosed RW (≥ 3 episodes/year) was assessed and multivariable logistic regression analyses performed to identify independent risk factors associated with RW.Results. 977 infants were enrolled. Table 1 displays the incidence of RW over the study period.View this table:Day care attendance was consistently identified as a risk factor (OR [95% CI]) for RW at 1 year (3.73, [2.30-6.03]), 2 years (2.21 [1.42-3.45]) and 3 years of age (2.90 [1.32-6.35]). Parental asthma (1 year; (1.94 [1.14-3.30]), and 3 years; (1.96 [1.07-3.60]), or acetaminophen use ≥ 1/pregnancy trimester (2 years (1.87[1.17-3.00]) and 3 years (1.95[1.15-3.31]) were identified as a risk factors at most ages. Lastly, at 1 year of age low birth weight (1.71, [1.06-2.76]) and school-age siblings (1.72 [1.10-2.71]) and at 3 years of age male gender (2.0 [1.18-3.33]) and animal contact during pregnancy (2.66 [1.02-6.93]) were also independenly associated with RW. Only palivizumab prophylaxis was shown to be protective for the development of RW at 3 years of age (0.30 [0.12-0.75]).Conclusions. Moderate to late preterm infants demonstrated significant respiratory morbidity during the first three years of life associated with several modifiable and non-modifiable risk factors.