PT  - JOURNAL ARTICLE
AU  - Rudy Sinharay
AU  - Ben Barratt
AU  - Charlotte Goward
AU  - Joao Pedro Rocha
AU  - Jim Zhang
AU  - Frank Kelly
AU  - Kian Fan Chung
AU  - Cullinan Paul
TI  - Cardio-respiratory outcomes in COPD following ambient exposures to diesel traffic emissions:"Oxford Street 2"
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - 3209
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/3209.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/3209.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Hypothesis: Airway dysfunction occurs in patients with COPD following exposure to diesel emissions together with inflammatory responses that cause vascular dysfunction.Methods: Using a cross-over design,volunteers walked along Oxford Street (OS: diesel traffic) and,on a separate occasion, in Hyde Park (HP). Cardio-respiratory measurements were performed at baseline, and during/after each exposure,alongside personal measurements of particulate matter (30 healthy and 24 COPD subjects).Findings: Compared to HP, OS exposures had higher levels of black carbon (6.5μm/m3 vs. 0.8μm/m3, p<0.001) and PM2.5(17.2 μm/m3 vs 5.2 μm/m3 p<0.01).In comparison with HP, healthy and COPD subjects had reductions in FEV1 during and after the OS walk. Small and large airway function changes measured by impulse oscillometry (IOS) were seen in the COPD group only. Arterial stiffness increased following the start of exposure on OS in both groups and, in those with COPD, persisted over 24 hours.View this table:Conclusions:Preliminary findings suggest airway dysfunction occurs in healthy and COPD subjects exposed to diesel emissions; COPD patients may also be more susceptible to prolonged vascular dysfunction.