PT  - JOURNAL ARTICLE
AU  - Hiroshi Iwamoto
AU  - Yasushi Horimasu
AU  - Taku Nakashima
AU  - Shinichiro Ohshimo
AU  - Nobuhisa Ishikawa
AU  - Kazunori Fujitaka
AU  - Yoshinori Haruta
AU  - Hiroshi Murai
AU  - Noboru Hattori
AU  - Witold Mazur
AU  - Nobuoki Kohno
TI  - Decreased circulatory receptor for advanced glycation end-products is associated with poorer survival in patients with idiopathic pulmonary fibrosis
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P741
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P741.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P741.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background: The receptor for advanced glycation end-products (RAGE) is highly expressed in alveolar type 1 pneumocytes and expression of RAGE is decreased in lung of idiopathic pulmonary fibrosis (IPF). However, there has been no study investigating circulatory RAGE levels in patients with IPF.Aim: We conducted this study to determine circulatory RAGE levels and the association between RAGE levels and survival in patients with IPF.Methods: Thirty-eight IPF patients and 81 control subjects were enrolled in this study. Serum concentrations of soluble RAGE (sRAGE) were measured using an enzyme-linked immunosorbent assay. Overall survival rates in IPF patients were analyzed by the Kaplan-Meier method applying cutoff values determined by the ROC curve analysis.Results: The median follow-up period for the patients with IPF was 20.6 months. Serum levels of sRAGE was significantly decreased in patients with IPF (569.0 ± 41.6 pg/ml) compared with control subjects (826.1 ± 37.6 pg/ml) (p < 0.001). The patients with IPF were categorized by their serum sRAGE levels (as above or below the cut-off level of 625 pg/mL) and their survival estimated using the Kaplan–Meier method. The difference in median survival between the two groups was significant (p < 0.05). The IPF patients with low levels of sRAGE (< 625 pg/mL) had shorter survival (2-year survival rate: 56%) compared with those with high levels of sRAGE (2-year survival rate: 100%).Conclusions: Circulatory sRAGE levels are decreased in patients with IPF compared with control subjects. Decreased sRAGE is associated with poorer survival in patients with IPF.