RT Journal Article
SR Electronic
T1 Systemic inflammation, diet, and place of residence modify lung function in Greenland Inuit
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 423
VO 44
IS Suppl 58
A1 Katherine Baines
A1 Vibeke Backer
A1 Peter Gibson
A1 Powell Heather
A1 Celeste Porsbjerg
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/423.abstract
AB Background: The preservation of lung health requires an understanding of the modifiable risk factors involved in airflow limitation. We aimed to determine the association between lung function, diet and systemic inflammation in a genetically homogenous population of Inuits residing in the arctic (Greenland) or Western Europe (Denmark).Methods: Two unselected Inuit populations were recruited, one living in Greenland (Urban (Nuuk) n=288; Rural (Uummannaq) n=183) and the other in Denmark (n=613). Lung function was measured using spirometry, and expressed as forced expiratory volume in one second (FEV1)/height (Ht). Systemic inflammation was measured by commercial enzyme linked immunoassay of serum C reactive protein (CRP), interleukin (IL)-6 and soluble CD163. Diet was assessed by food frequency questionnaire. Predictors of airflow limitation were assessed using multiple linear regression models.Results: The dietary composition differed significantly in the two regions, with high fish intake and low fruit intake in the arctic region and the reverse in Denmark. Consumption of wild meat (p=0.020), fish (p=0.025), and fruit (p=0.020); were positive predictors of FEV1/Ht ratio. Whereas systemic inflammation, determined by a high CRP (p=0.0001), IL-6 (p=0.003) and sCD163 (p=0.001), was associated with lower lung function.Conclusions: Among Greenlandic Inuits, lung function is associated with potentially modifiable risk factors including systemic inflammation and dietary intake. Specifically, high wild meat, fish and fruit intake had independent positive effects on lung function. These factors may play an important role in determining overall lung health.