RT Journal Article
SR Electronic
T1 Adaptation of the GLI- 2012 spirometry reference equations for use in Indian children
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 191
VO 44
IS Suppl 58
A1 Jane Kirkby
A1 Sooky Lum
A1 Janet Stocks
A1 Rachel Bonner
A1 Samatha Sonnappa
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/191.abstract
AB Background: The Global Lung Function Initiative (GLI) produced the first global all-age, multi-ethnic reference equations for spirometry (Quanjer, ERJ 2012) but lacked equations for South Asians.Aim: To derive spirometry coefficients for Indian children based on GLI-2012 equations.Methods: Identical anthropometry and spirometry were undertaken in healthy Indian children participating in the Size and Lung Function in Children study in London, UK and Bangalore, India. We have previously shown that anthropometry and lung function were similar between Indian children living in Bangalore city and those living in London (Kirkby, ERS-2013 abstract). Data from both centres were pooled to derive a new coefficient for Indian children using GLI software (www.lungfunction.org).Results:Spirometry data from healthy Indian children <12y born in the UK (n=429) and India (n=382) were available. Compared to White children, FEV1 was 11% lower [mean (95%CI) -0.98z-scores (-0.99; -0.97)] in Indian children. A proportional reduction in FVC was observed such that FEV1/FVC was constant between groups (Figure1). After deriving and applying the new coefficients for Indian children, the mean (SD) for FEV1, FVC and FEV1/FVC z-scores approximated 0(1)Conclusion: The derivation of GLI-coefficients from healthy Indian children will facilitate interpretation of spirometry data in Indian children with lung disease.