RT Journal Article
SR Electronic
T1 Prevalence of occupational and environmental exposures in Australian patients with idiopathic pulmonary fibrosis (IPF)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4551
VO 44
IS Suppl 58
A1 E. Haydn Walters
A1 Michael J. Abramson
A1 Geza Benke
A1 Shyamali Dharmage
A1 Ian Glaspole
A1 Ryan Hoy
A1 Sacha Macansh
A1 Tamera J. Corte
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P4551.abstract
AB Background: IPF is a fatal lung disease, with no current effective treatment. IPF is considered idiopathic by definition, but key environmental exposures may be important to its pathogenesis. Methods:The Australian IPF Registry is a national cohort of IPF patients. Data collected include a questionnaire with detailed exposure history to tobacco, environment, and dust exposures. The prevalence of exposures and associations between rate of exposure and IPF were explored. Results: 377 patients have consented to the Registry. 299 (79%) have completed exposure questionnaires (mean±SD: age 70.9±8.0yrs; 202 male; FVC 82.5±22.8%predicted). Smoking history: 204 ex-smokers, 9 current smokers, 85 non-smokers. Environmental exposures are reported in Table 1. Occupational exposures include asbestos 115 (40.8%; 95%CI: 35.2, 46.6),silica 37 (13.0%; 9.5, 17.4), chemicals 136 (47.1%; 41.4, 52.8) and dusty environments 153 (52.0%; 46.3, 57.7). The IPF rate in geographic areas correlated with exposure rate to chemicals (r=0.86, p=0.01) and dusty environments (r=1.0; p<0.001). Conclusion: IPF patients report a high prevalence of potentially adverse exposures, and exploratory analyses show a geographic relationship between some exposures and IPF. Further case control studies are needed to determine if these exposures are more prevalent in IPF patients than healthy controls.View this table:Environmental exposures