TY - JOUR T1 - Differences in functional impairment diagnosis using global lung initiative (GLI) predictive values for spirometry JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - 217 AU - Diana Ionita AU - Marina Lazar AU - Roxana Silvia Bumbacea AU - Gabriela Weiss AU - Cornelia Tudose AU - Dragos Bumbacea Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/217.abstract N2 - Aim To assess the differences in functional impairment diagnosis in Romanian subjects with various lung diseases using two sets of predictive values for spirometry: ERS93 (obtained from a 25-70 years old West-European population) and the new GLI equations.Methods Spirometry sessions performed using ATS/ERS quality criteria were evaluated. Predicted values, lower limit of normal and %predicted for FVC, FEV1, FEV1/FVC, FEF25-75 and MEF25 were compared using GLI and ERS93 equations in subjects with various ages, gender or heights. Functional impairment was assessed using ATS/ERS recommendations.Results Spirometry was evaluated in 124 consecutive subjects aged 18-82 years, height 1.50-1.93m, 54 males.Using GLI set, FVC and FEV1 %predicted were lower than using ERS93 set (mean difference in percent-points -8±4 for FVC, -4±3 for FEV1), while FEF25-75 and MEF25 %predicted values were higher (mean difference 10±9 for FEF25-75, 39±32 for MEF25). Differences were significantly larger in older (>70yo), shorter (<1.55m), and female subjects (p<0.05).Normal spirometry was seen in 53 subjects using GLI and in 64 using ERS93 (in 52 concordantly); impairment severity was concordant in 49 subjects.Restriction was diagnosed in 28 subjects (23%) using GLI and in only 14 (11%) using ERS93, while obstruction in 56 (45%) and 52 (42%) respectively.Conclusion In this Romanian population we found significant differences in spirometric values using GLI versus ERS93, larger for women, shorter and older subjects. Functional diagnosis was non-concordant in 23 subjects (18%), with more spirometric restrictions and obstructions diagnosed using GLI equations and more severe impairments. ER -