PT - JOURNAL ARTICLE AU - Gulsah Bargi AU - Meral Bosnak Guclu AU - Zeynep Aribas AU - Elif Sakizli AU - Burcu Camcioglu AU - Muserrefe Nur Karadalli AU - Zeynep Arzu Yegin AU - Sahika Zeynep Aki AU - Gulsan Turkoz Sucak TI - Functional exercise capacity, respiratory and peripheral muscle strength, pulmonary functions and dyspnea in allogeneic hematopoietic stem cell transplantation candidates DP - 2014 Sep 01 TA - European Respiratory Journal PG - P4331 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P4331.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P4331.full SO - Eur Respir J2014 Sep 01; 44 AB - Background: Although respiratory and skeletal muscle strength and submaximal exercise capacity are known to be reduced in a significant percentage of patients prior to hematopoietic stem cell transplantation (HSCT). Comparison of pre-allogeneic HSCT recipients' functional exercise capacity, muscle strength, pulmonary functions and dyspnea with healthy subjects have not been investigated previously.Aim: To comparatively investigate the functional exercise capacity, pulmonary functions, muscle strength, and dyspnea in pre-allogeneic HSCT recipients.Methods: A prospective, cross sectional study. Twenty seven HSCT candidates (42.04±12.64) and 31 healthy subjects (46.13±10.06) were included. Functional exercise capacity was evaluated using 6 minute walk test (6MWT), pulmonary functions using a spirometry, respiratory muscle strength (MIP, MEP) using a mouth pressure device, peripheral muscle strength using dynamometer, dyspnea using Modified Medical Research Council Dyspnea scale (MMRC) and Modified Borg scale.Results: HSCT candidates' 6MWT distance, MIP, MEP were significantly lower, exertional dyspnea, dyspnea in activities of daily living were higher compared to healthy subjects (p<0.05). Pulmonary functions and peripheral muscle strength were similar in groups (p>0.05).Conclusions: Functional exercise capacity and respiratory muscle strength are impaired, dyspnea is worsened and pulmonary functions and peripheral muscle strength are preserved in patients prior to allogeneic HSCT. Possible mechanisms and the effects of aerobic exercises and inspiratory muscle training should be investigated prior to allo-HSCT.