TY - JOUR T1 - Prevalence of interlobar collateral ventilation in COPD patients JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P3714 AU - Dominik Herzog AU - Stefan Hippenstiel AU - Dirk Schürmann AU - Felix Döllinger AU - Alexander Pöllinger AU - Bettina Temmesfeld-Wollbrück AU - Norbert Suttorp AU - Ralf-Harto Hübner Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P3714.abstract N2 - The prevalence and distribution of collateral ventilation (CV) in emphysematous lungs are not well-described endobronchially under physiological conditions. Recently, an endobronchial catheter (Chartis, Pulmonx) has become routine in the clinical evaluation of CV status, which is important for clinical success in endoscopic lung volume reduction (ELVR) with endobronchial valves (EBV).The distribution of 325 Chartis assessments of 125 COPD patients with severe emphysema was analyzed and classified according to 4 phenotypes: CV positive (CV+), CV negative (CV-), Low Flow (LF) and Low Plateau (LP), using measurements of increases in resistance index, changes in total exhaled volumeand decline in expiratory flow. Analysis focused on patients having completed measurements in both left and right lung to assess suitability for EBV treatment. Respective lungs were considered CV- if at least one lobe had no collateral ventilation detected. The Chi-squared test was used for statistical analysis.80 patients had at least one measurement in each lung. CV status results are summarized in the table.View this table:CV status of 80 patientsLeft lungs were more frequently observed to be CV- than right lungs (68.75% vs. 32.5% p=0.03). Only 27.5% of the patients had both CV+ left and right lungs.In this study, bilateral Chartis lung measurements showed that 72.5% of the patients with severe emphysema COPD had at least one lobe that was absent of collateral ventilation. Left lung demonstrated less frequent collateral ventilation than right lung and may be a better target for valve therapy. ER -