RT Journal Article SR Electronic T1 Markers of bone metabolism in men with chronic obstructive pulmonary disease (COPD) aged 40-70 years JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3607 VO 44 IS Suppl 58 A1 Sviatlana Lemiasheuskaya YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P3607.abstract AB Aim was to study the imbalance of markers of bone metabolism in men with COPD.Methods: Bone markers b-crosslaps (b-CTX) and osteocalcin were determined by the electrochemiluminiscence immunoassays.We examined 3 groups of patients and control group (15 healthy men). The COPD pts were subdivided into groups according to COPD severity: the 1st was made of 20 men; GOLD I degree; mean age 55 years; BMI 27 kg/m2; the 2nd included 43 patients; GOLD II degree; mean age 57; BMI 28 kg/m2; the 3d -20 patients; GOLD III degree; mean age 60; BMI 24,5 kg/m2.Results: The level of b-CTX (bone resorption marker) increased during COPD progression: in the control – 0.29 ng/ml; 1st group – 0.30; 2nd– 0.40 and 3rd group – 0.37; p < 0.05 vs. the control and the 1st group. b-crosslaps was elevated in 5% patients in the 1st group, in 24% patients in the 2nd group (p = 0,12). Increased b-crosslaps was noted in 11% patients in the 3rd group, but without significant differences with 1st and 2nd groups (p = 0.96 and p = 0.46, respectively). Osteocalcin level (bone formation marker) was decreased in 32% patients in the 1st group and 45% in the 2nd group (p = 0.35). Osteocalcin was reduced in 47% patients in the 3rd group, but with no significant differences with 1st and 2nd groups (p = 0.31 and p = 0.86, respectively).Conclusions: Bone metabolic imbalance caused predominantly disturbance of bone formation then increasing bone resorption in men with COPD. This is supported by a significant number of patients (43%) with a marked reduction of osteocalcin as compared with patients (9%) with high level of b - crosslaps (p<0.001).