TY - JOUR T1 - SP-D as a biomarker for COPD in the Lebanese population JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4767 AU - Zeina Akiki AU - Dalia Fakih AU - Rania Jounblat AU - Souleima Chamat AU - Mirna Waked AU - Grith Sorensen AU - Rachel Nadif AU - Pascale Salameh Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4767.abstract N2 - Background: Surfactant protein D (SP-D), a promising systemic biomarker of chronic obstructive pulmonary disease (COPD) was never evaluated in the Lebanese population.Objective: The validity of serum SP-D as a biomarker for COPD, in comparison with C-reactive protein (CRP) and fibrinogen was investigated. Associations between SP-D levels and lung function tests and the value of combining SP-D and the Diagnosis Score of COPD (DS-COPD) for COPD diagnosis were also evaluated.Methods:90 COPD patients and 452 controls were recruited. Standardized questionnaires, lung function tests, COPD diagnosis (GOLD 2013), and blood collection were performed. Serum SP-D and CRP, and plasma fibrinogen levels were measured by ELISA. Associations between biological markers with lung function parameters and COPD were estimated by spearman correlation and logistic regression models respectively.Results: Median serum SP-D levels for COPD patients were 1510 ng/mL (from 986 to 2174 ng/mL). SP-D levels were positively associated with age and pack-years in controls (all p<0.01). SP-D levels above the median value were positively associated with COPD (adjusted OR (aOR)=2.86, 95%CI: 1.37-5.98). Higher DS-COPD values (aOR=1.8, 1.49-2.16) and SP-D levels above the median value (aOR=3.51, 1.21-10.1) were significantly and independently associated with COPD in patients and healthy controls aged 40 years or above. No associations were found between CRP, fibrinogen levels and COPD, or between SP-D levels and lung function tests.Conclusion: SP-D seems to be a more reliable biomarker than CRP or fibrinogen for COPD diagnosis in the Lebanese population. Used with the DSCOPD, the SP-D measure could provide a simple and inexpensive tool for COPD diagnosis. ER -