RT Journal Article
SR Electronic
T1 Nasal and exhaled nitric oxide in the specific inhalation challenge
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4538
VO 44
IS Suppl 58
A1 Irmeli Lindström
A1 Anne Puustinen
A1 Hille Suojalehto
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P4538.abstract
AB Aim: To evaluate the feasibility of nasal (NNO) and exhaled nitric oxide (FENO) in the diagnostics of occupational rhinitis (OR) and asthma (OA).Methods: A placebo controlled specific inhalation challenge (SIC) was performed to 162 subjects with suspected OA. NNO and FENO were measured using an on-line chemiluminescence analyser (NIOX, Aerocrine AB, Solna, Sweden) before each challenge, 6-8 hours and 24 hours after each challenge. The significant score change in both nostrils confirmed the positive nasal reaction (Hytonen M. et al Rhinology 1996:34;86-90) and an objectively detected increase in nasal symptoms with non-significant score change the suggestive reaction. FEV1 decline by ≥15% of the pre-challenge value determined the positive bronchial reaction and FEV1 decline by<15% with symptoms the suggestive reaction.Results: A significant increase in NNO was detected 6-8 hours after the challenge in subjects with a positive nasal reaction (Table 1) and in FENO 24 hours after the challenge in subjects with positive bronchial reaction (p=0.013).Conclusions: Increases in NNO and FENO may support positive reactions in SIC. The best time point for measuring the NNO seems to be 6-8 hours after exposure.View this table:Table 1