RT Journal Article SR Electronic T1 Phase angle versus conventional bioelectric impedance analysis in patients hospitalised with an acute exacerbation of COPD JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P4486 VO 44 IS Suppl 58 A1 Sarah Jones A1 Samantha Kon A1 Jane Canavan A1 Claire Nolan A1 Mandy Dickson A1 Brigette Haselden A1 Paul Cullinan A1 Michael Polkey A1 William Man YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P4486.abstract AB Introduction Bioelectric impedance analysis (BIA) is a non-invasive bedside method used to estimate body composition. However, validity of estimates are dependent on multiple assumptions that are frequently violated in sick and hospitalised patients. Raw impedance parameters, such as phase angle (PA) are less affected by hydration status and fluid shifts.Hypothesis PA may be a better indicator of body composition than conventional BIA-derived fat free mass (FFM) in patients hospitalised with AECOPD.Method PA, FFM (Bodystat 4000), 4-metre gait speed(4MGS), five-repetition sit-to-stand(5STS), quadriceps maximum voluntary contraction(QMVC) and handgrip strength(HG) were measured at discharge in 209 patients hospitalised for AECOPD. Pearson's correlations were used to assess the relationship between PA and FFM with muscle strength and physical performance.Results Cohort characteristics were:53%male; mean(SD) age 72(11);BMI 26.5(6.9);FEV1%pred 40(20); MRC dyspnoea score 4(1); median(IQR) length of stay 3(1,5). Correlations between PA and FFM with muscle strength and physical performance are shown in Table 1. FFM did not correlate significantly with 4MGS,5STS,QMVC or HG.Conclusion Conventional BIA-derived FFM does not correlate with parameters of muscle strength and physical performance in hospitalised patients with COPD. Raw impedance parameters such as phase angle are better indicators of muscle health in hospitalised patients with COPD.View this table:Correlations with Phase Angle and FFM