RT Journal Article
SR Electronic
T1 Does exercising COPD patients on non invasive ventilation (NIV) enable them to walk further? A randomised controlled trial
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4711
VO 44
IS Suppl 58
A1 Kathryn Buchan
A1 Kathryn Badlan
A1 Margaret Fletcher
A1 Adrian Kendrick
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P4711.abstract
AB Background: The exercise component of pulmonary rehabilitation (PR) can improve activity in patients with severe COPD. However, these patients are repeatedly hospitalised, deconditioned and cannot access PR. NIV may offload the respiratory muscles relieving breathlessness allowing patients to train, which may increase fitness enabling patients to walk further. Aim: To identify potential differences in 6 minute walk test (6MWT) between patients with severe COPD who exercise on NIV and those receiving standard care. Method: 18 patients with COPD (11 female, mean age 66.5 years [46-97], FEV1: mean 25% predicted [9-51%], MRC mean score 3 [1-4]) recruited following an admission for an exacerbation of COPD requiring treatment with NIV were randomised to 3 groups. Group 1 received standard hospital physiotherapy care, Group 2 exercised on NIV (Trilogy 100, Philips-Respironics) with a PS of 10 (10-16) twice weekly for the duration of the admission and Group 3 exercised on NIV during hospital stay and also twice weekly for 3 months following discharge. Exercise in all 3 groups included weights and pedal cycling or walking. All were followed up monthly for 3 months and 6MWT was measured. Results: Group 1: At baseline 6MWT was mean 49m (0-306m) and at end of study 6MWT was 40m (0-216m). Group 2: At baseline was 17m (0-38m) and at month 3 6MWT was 26m (5-70m). Group 3: At baseline 6MWT was 71m (0-315m) and at month 3 6MWT was 218m (84-494m). 15/18 final measures completed to date and 3/18 died during the study period. Conclusions:There is a trend that the patients in group 3 had improved 6MWT compared to those in group 1 who demonstrated a decline in their 6MWT.