TY - JOUR T1 - U-BIOPRED: Clinical characteristics of children with severe asthma (SA) and severe pre-school wheeze (SPSW) JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4220 AU - Louise Fleming AU - Ana Sousa AU - Clare Murray AU - Simone Hashimoto AU - Gunilla Hedlin AU - Julie Corfield AU - Rowe Anthony AU - Florian Singer AU - Urs Frey AU - Hans Bisgaard AU - Andrew Bush AU - Scot Wagers AU - Kian Fan Chung AU - Dominick Shaw AU - Stephen Fowler AU - Ioannis Pandis AU - Christopher Compton AU - Wolfgang Seibold AU - Aruna Bansal AU - Peter Sterk AU - Graham Roberts Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4220.abstract N2 - Rationale: U-BIOPRED aims to sub-phenotype SA through the life course of the disease, using an innovative systems biology approachMethods: Children with SA and SPSW (defined in Thorax 2011;66:910) and mild-moderate controls were recruited. Data regarding demographics, exacerbations, quality of life (QoL), asthma control, lung function and FENO were collected.Results: 272 children were enrolled. QoL scores were lowest in the SPSW cohort. They also had frequent exacerbations. Urinary cotinine was more often positive in children with SPSW compared to controls (20% vs 2.3% p=0.006) and their mothers were more likely to have smoked during pregnancy (13.8% vs 0% p=0.006).View this table:Conclusions: These preliminary data confirm that severe paediatric cohorts have poor QOL despite significant treatment and are frequently exposed to tobacco smoke. There arevclear unmet needs in the management of these children. Integration of the clinical with high dimensional datasets will help to define sub-phenotypes. ER -