TY - JOUR T1 - EBUS-TBNA for nodal restaging and relapse in lung cancer JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2754 AU - Markus Enderle AU - Petra Hoffknecht AU - Gabriela May AU - Heiner Schubert AU - Stefan RĂ¼ther AU - Stefan Fischer AU - Patrick Zardo AU - Nicolas Dickgreber Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2754.abstract N2 - PET-CT and EBUS are current standard procedures for mediastinal lymph node (ln) staging of patients (pat.) with lung cancer (BC). Few publications however focus on restaging and ln recurrence after previous therapy. In this single center retrospective study of a newly established department of respiratory medicine this subgroup is evaluated.From 08/11 to 01/14 we performed EBUS-TBNA in 25 pat. with BC under suspicion of ln recurrence or for restaging (n=20 NSCLC, n=5 SCLC). Primary staging resulted in UICC 7th edition I/II in n=9 pat. IIIa/b in n=13 and IV in n=3. Diagnostic workup included CT-scan in all pat. and PET-CT in n=20. In 14/25 pat. ln metastases could be confirmed, in 10 pat. by EBUS-TBNA and in 4 pat. by subsequent surgery. 2 of these finally resulted in pN1 and 2 pN2. A further pat. refused further diagnostic but had clinical progressive disease. Pat. with negative EBUS-TBNA result (11/25) received further follow up or continued tumor treatment without developing ln relapase in 6 pat.. In one pat. surgery confirmed pN0 status. Overall EBUS-TBNA had a sensitivity and specificity of 71,4% and 54,5%.13 of 25 pat. were initially staged UICC IIIa/b. Previous treatment in this subgroup comprised platinum based chemoradiation (n=10), neoadjuvant chemotherapy (n=2) and one resection. 9/13 underwent PET-CT, 5 of these 9 finally showing ln metastases. 2/5 show concordant avid ln in PET-CT. 3/5 showed false negative PET-CT. EBUS diagnosed correctly 4 of 7 finally confirmed malignant ln with a sensitivity and specificity of 57% and 46%. PET-CT shows a sensitivity of 40%.We consider EBUS-TBNA as a reliable method for confirming malignancy in pat. with known BC. Negative TBNA results however need to undergo surgical workup. ER -