TY - JOUR T1 - Identification of atopy amongst wheezing infants via electronic nose JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4202 AU - Marc P. van der Schee AU - Simone Hashimoto AU - Marlous van den Ouweland AU - Nora Adriaens AU - Anne-Marie C. Schuurman AU - Aline B. Sprikkelman AU - Eric G. Haarman AU - Wim M.C. van Aalderen AU - Peter J. Sterk Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4202.abstract N2 - Rationale: Infants with physician confirmed wheeze have higher risk of developing asthma. Moreover, there is increased evidence on the role of atopy as contributor to a high risk phenotype for severe airway diseases. Non-invasive biomarkers have been used in the assessment of various clinical and inflammatory characteristics.We aimed to determine whether electronic nose (eNose) can identify atopic sensitization to common allergens amongst wheezy infants.Methods: Cross-sectional analysis from the EUROPA study (n=1212), an unbiased birth cohort aimed at early diagnose of asthma in infants. Wheeze was confirmed by a trained physician during a period of acute respiratory symptoms. Blood and exhaled breath were collected in wheezy infants and healthy controls (no history of wheeze or dyspnea). Specific IgE was investigated by ImmunoCAP Immuno Solid-phase Allergen Chip (Phadia, Sweden) and exhaled breath was analyzed by eNose. Raw eNose data was analyzed using principal component and discriminant analysis and ROC-curves were constructed.Results: 64 wheezy infants (42 male, 29.2±3.2months) and 73 healthy controls (38 male, 26.9±2.4 months) were included. Sensitization to any allergen (cut-off 0.3 ISU) was present in 49 (79%) and 51 (69%) infants, respectively. Breath prints differed significantly between wheezy infants sensitized and not sensitized (AUC of ROC = 0.74±0.07, p value=0.008). There were no differences in the exhaled breath profiles between healthy controls sensitized and not sensitized (p value=0.14).Conclusion: eNose can discriminate atopic and non-atopic wheezy infants with moderate accuracy. These findings support the added value of non-invasive biomarkers in the phenotyping of wheezy infants. ER -