TY - JOUR T1 - Trajectories of specific IgE in the PASTURE birth cohort study JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4248 AU - Alexander Hose AU - Martin Depner AU - Charlotte Braun-Fahrländer AU - Juha Pekkanen AU - Josef Riedler AU - Jean-Charles Dalphin AU - Jon Genuneit AU - Roger Lauener AU - Petra Ina Pfefferle AU - Erika Von Mutius AU - Markus Ege Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4248.abstract N2 - BackgroundIgE sensitisation patterns have been shown to change within the first 12 months of life and to be determined by maternal and environmental influences (Depner et al., JACI 2013; 131:781-8).ObjectiveTo explore the course of atopic sensitisation between birth and 6 years of age in the context of a farming environment.MethodsSpecific IgE levels for 6 food and 13 common inhalant allergens were assessed in cord blood and in peripheral blood at age 1, 4, and 6 years in the PASTURE (Protection against Allergy–Study in Rural Environments) birth cohort (n=1133) from rural regions of 5 European countries.ResultsUsing a cut-off of 0.35 kU/L (RAST class 1), the prevalence of sensitisation to any allergen was 28% at year 1, 58% at year 4, and 54% at year 6. The steep increase between year 1 and 4 was also accompanied by a switch from RAST class 1 to 3 in about 20% of sensitised children.Figure 1 illustrates diverse sensitisation patterns for farm and non-farm children with respect to seasonal and food allergens. Food sensitisation was more common in farm children only at lower levels, whereas seasonal sensitisation was more common in non-farm children at any level. Prevalence of sensitisation to perennial allergens did not differ between farm and reference children and peaked at 4 years at 30%.ConclusionGrowing up on a farm might alter sensitisation patterns possibly revealing a modified immune response with a limited production of specific IgE. ER -