@article {HoseP4248, author = {Alexander Hose and Martin Depner and Charlotte Braun-Fahrl{\"a}nder and Juha Pekkanen and Josef Riedler and Jean-Charles Dalphin and Jon Genuneit and Roger Lauener and Petra Ina Pfefferle and Erika Von Mutius and Markus Ege}, title = {Trajectories of specific IgE in the PASTURE birth cohort study}, volume = {44}, number = {Suppl 58}, elocation-id = {P4248}, year = {2014}, publisher = {European Respiratory Society}, abstract = {BackgroundIgE sensitisation patterns have been shown to change within the first 12 months of life and to be determined by maternal and environmental influences (Depner et al., JACI 2013; 131:781-8).ObjectiveTo explore the course of atopic sensitisation between birth and 6 years of age in the context of a farming environment.MethodsSpecific IgE levels for 6 food and 13 common inhalant allergens were assessed in cord blood and in peripheral blood at age 1, 4, and 6 years in the PASTURE (Protection against Allergy{\textendash}Study in Rural Environments) birth cohort (n=1133) from rural regions of 5 European countries.ResultsUsing a cut-off of 0.35 kU/L (RAST class 1), the prevalence of sensitisation to any allergen was 28\% at year 1, 58\% at year 4, and 54\% at year 6. The steep increase between year 1 and 4 was also accompanied by a switch from RAST class 1 to 3 in about 20\% of sensitised children.Figure 1 illustrates diverse sensitisation patterns for farm and non-farm children with respect to seasonal and food allergens. Food sensitisation was more common in farm children only at lower levels, whereas seasonal sensitisation was more common in non-farm children at any level. Prevalence of sensitisation to perennial allergens did not differ between farm and reference children and peaked at 4 years at 30\%.ConclusionGrowing up on a farm might alter sensitisation patterns possibly revealing a modified immune response with a limited production of specific IgE.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P4248}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }