RT Journal Article SR Electronic T1 Comparing non-invasive cardiovascular risk assessment tools in COPD patients: Validation with CV events JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P4105 VO 44 IS Suppl 58 A1 Jorge Zagaceta A1 Javier Zulueta A1 Gorka Bastarrika A1 Inmaculada Colina A1 Arantza Campo A1 Ana Belen Alcaide A1 Pablo Sánchez A1 Juan Bertó A1 Pilar Rivera A1 Bartolome Celli A1 Juan Pablo de Torres YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P4105.abstract AB Rationale: COPD is an independent risk factor for coronary artery disease (CAD) and cardiovascular (CV) disease is one of the main causes of death in COPD patients.Objectives: Compare the different non-invasive CV risk tools in COPD patients.Methods: COPD patients of all degree of severity were prospectively recruited from January 2001 to August 2012. At enrollment we measured: lipid profile, CRP, urine albumine/creatinine ratio, Framingham, SCORE, BODE and its components, coronary artery calcium (CAC) and epicardial adipose tissue (EAT). Their predictive power of CV events was then compared.Results: Patients characteristics are shown in Table 1.The median follow-up was 34 months (IQR: 7.8 to 72 months) with a total of 84 recorded CV events: 20 (24%) AMI, 19 (21%) ischemic heart disease/angina, 28 (34%) peripheral artery disease and 18 (21%) strokes.Twelve deaths ocurred, 3 (25%) from CV disease. Table 2 shows the univariate analysis exploring the independent association of each of the risk assessment tools with the ocurrence of CV event. Table 3 shows the multivariate analysis identifying those with the best predictive power. The under area curve (UAC) were: CAC (c statistic = 0.65), Framingham (c stat=0.602), SCORE (c stat=0.55), EAT (c stat=0.52) and 6MWD (c stat=0.65).Conclusions: In this population of well-characterised COPD patients, CAC and the 6MWD were the best independent predictors of CV events.