RT Journal Article
SR Electronic
T1 Eosinophilic phenotypes of overlapping respiratory diseases in an Italian general population sample
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4084
VO 44
IS Suppl 58
A1 Sonia Cerrai
A1 Marzia Simoni
A1 Sara Maio
A1 Giuseppe Sarno
A1 Sandra Baldacci
A1 Anna Angino
A1 Franca Martini
A1 Francesco Pistelli
A1 Laura Carrozzi
A1 Giovanni Viegi
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P4084.abstract
AB Aim: to quantify the distribution of overlapping diagnosis of Asthma (A), Chronic Bronchitis (CB) and Emphysema (E), stratifying by blood eosinophilia (EOS+/EOS-). To evaluate the role of environmental/host risk factors for eosinophilic phenotypes of A and COPD (CB+E).Methods: 1919 subjects (8-88 yrs, 49% males) enrolled in an Italian cross-sectional study (1991-93), filled in a questionnaire on respiratory symptoms/diseases and risk factors and underwent a blood test. Eosinophil count is expressed as % of total leucocytes (EOS+ >3%). A double proportional Venn diagram is used to show the distribution of A, CB, E and their overlapping categories. A Multinomial Logistic Regression were run to assess the association of A or COPD eosinophilic phenotypes with gender, age, smoke, work exposure, eczema, rhinitis and diagnosis of asthma or COPD (Odd Ratio–OR, Confidence Interval–CI 95%).Results:AsmaEOS+ and AsmaEOS- are associated with COPD (OR 5.1 vs 6.9) and rhinitis (6.3 vs 2.4); AsmaEOS+ is also associated with age<25 (3.1) and smoke (0.4). As for COPD, we pinpoint the association of COPDEOS+ and COPDEOS- with work exposure (3.3 vs 1.6) and the association of COPDEOS- with rhinitis (0.4).Conclusions: eosinophilic pattern is more frequent in young people and generally EOS+ subjects tend to be non smokers. The results confirm the expected overlap among respiratory diagnosis and show higher values in EOS- condition.