RT Journal Article
SR Electronic
T1 Relationship between hepcidin levels and periodic limb movements in sleep in patients with obstructive sleep apnea syndrome
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2202
VO 44
IS Suppl 58
A1 Ozlem Abakay
A1 Abdurrahman Abakay
A1 Yilmaz Palanci
A1 Hatice Yuksel
A1 Hadice Selimoglu Sen
A1 Osman Evliyaoglu
A1 Abdullah Cetin Tanrrikulu
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2202.abstract
AB Objectives: A new proposed marker of hypoxia, Hepcidin, may identify at-risk patients with obstructive sleep apnea syndrome (OSAS). Periodic limb movement (PLM) in sleep is characterized by periodic episodes of repetitive and stereotypic limb movements during sleep.Aim: This study was aimed to assess potential correlations between PLM index, hepcidin levels and iron status in patients with OSAS.Methods: Forty-four newly diagnosed OSAS patients and 49 nonapneic controls were enrolled in this study. Demographic data, cigarette smoking status, previous history of other diseases and drugs were obtained by a standardized questionnaire. All patients underwent polysomnographic evaluation. The hepcidin, iron, ferritin,TIBC, and C-reactive protein (CRP) levels were measured.Results: The mean age was 47.4±7.2 (18–68) years in the OSAS group and 44.9±11.1 (23–65) years in the control group. There were no differences in age, gender and smoking between OSAS patients and controls. Mean apnea–hypopnea index (AHI) was 25.1 events/h. Mean serum hepcidin levels were significantly higher in OSAS subjects (725.9 ng/ml) than in control subjects (646.0 ng/ml) (P <0.001). Serum iron levels were significantly lower in the OSAS and PLM disorders groups than in control subjects (P <0.001).Serum hepcidin levels were significantly correlated with AHI (r = 0.453), and PLMI (r = 0.114). Serum iron levels were significantly negatively correlated with AHI (r =-0.169) and PLMI (r =-0.032).ConclusionIn our study, the level of hepcidin was increased in patients with OSAS. We suggest that levels of hepcidin correlate with the AHI and PLM index severity of OSAS.