RT Journal Article
SR Electronic
T1 Ventilatory parameters on cardiopulmonary exercise testing in advanced heart failure: Chagas versus ischemic etiology
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2159
VO 44
IS Suppl 58
A1 Laura Maria Tomazi Neves
A1 Alexandra Corrêa Gervazoni Balbuena de Lima
A1 Maria Estefânia Bosco Otto
A1 Marianne Lucenna da Silva
A1 Vinícius Zacarias Maldaner da Silva
A1 Cláudio Hiroshi Nakata
A1 Filippe Vargas de Siqueira Campos
A1 Fellipe Amatuzzi Teixeira
A1 Ross Arena
A1 Gerson Cipriano Júnior
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2159.abstract
AB Background: A hallmark symptom of heart failure (HF) is breathlessness and a potential cause is the reduced ventilatory efficiency . Exercise capacity (EC), expressed as peak oxygen consumption (VO2peak), is one of the best predictors of prognosis in HF. Nevertheless, the exercise ventilatory response in Chagas has not been fully comprehended.Objective:To examine the relationship between exercise ventilation indices and EC on cardiopulmonary exercise testing (CPX) in Chagas (CH) and Ischemic (IS) HF cohorts as well as healthy controls (HC).Methods: Fifty-eight male HF patients (31 IS and 27 CH) and 19 HC matched by age (p=0,30) and body mass index (p=0,17) were included in this analysis. Patients with with IS or CH etiology in current standard medical therapy use underwent symptom limited CPX in treadmill. Patients with pulmonary disease were excluded.Results: HF patients presented LV systolic disfunction (p=0,14), lower peak VO2 (IS: 20,2+/-7,6ml/kg.min and CH: 20,7+/-8,6ml/kg.min, p=0,97), lower VE (IS: 50,9+/-16,9ml/min, CH: 54,7+/-19,4 ml/min, p= 0,63); higher ventilatory reserve (VR) (IS: 93,3+/-23,3ml/min; CH: 78,8+/-18,3ml/min, p=0,024) signficant diferent comparing to control group (all p<0,0001). There was correlation between VO2 peak and VE (IS: r=0,48, p=0,006; CH: r=0,49, p=0,008); and a inverse correlation between aerobic condition and ventilatory reserve (IS: r=-0,49, p=0,005; CH: r=-0,58, p=0,001).Conclusions: In patients with advanced HF, IS or CH etiology, EC was inversely related to VR. Exercise breathlessness seems to be related to inefficiency using of VR. This reinforces the importance of specific respiratory muscles training in HF.