PT - JOURNAL ARTICLE AU - Laura Maria Tomazi Neves AU - Alexandra Corrêa Gervazoni Balbuena de Lima AU - Maria Estefânia Bosco Otto AU - Marianne Lucenna da Silva AU - Vinícius Zacarias Maldaner da Silva AU - Cláudio Hiroshi Nakata AU - Filippe Vargas de Siqueira Campos AU - Fellipe Amatuzzi Teixeira AU - Ross Arena AU - Gerson Cipriano Júnior TI - Ventilatory parameters on cardiopulmonary exercise testing in advanced heart failure: Chagas versus ischemic etiology DP - 2014 Sep 01 TA - European Respiratory Journal PG - P2159 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P2159.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P2159.full SO - Eur Respir J2014 Sep 01; 44 AB - Background: A hallmark symptom of heart failure (HF) is breathlessness and a potential cause is the reduced ventilatory efficiency . Exercise capacity (EC), expressed as peak oxygen consumption (VO2peak), is one of the best predictors of prognosis in HF. Nevertheless, the exercise ventilatory response in Chagas has not been fully comprehended.Objective:To examine the relationship between exercise ventilation indices and EC on cardiopulmonary exercise testing (CPX) in Chagas (CH) and Ischemic (IS) HF cohorts as well as healthy controls (HC).Methods: Fifty-eight male HF patients (31 IS and 27 CH) and 19 HC matched by age (p=0,30) and body mass index (p=0,17) were included in this analysis. Patients with with IS or CH etiology in current standard medical therapy use underwent symptom limited CPX in treadmill. Patients with pulmonary disease were excluded.Results: HF patients presented LV systolic disfunction (p=0,14), lower peak VO2 (IS: 20,2+/-7,6ml/kg.min and CH: 20,7+/-8,6ml/kg.min, p=0,97), lower VE (IS: 50,9+/-16,9ml/min, CH: 54,7+/-19,4 ml/min, p= 0,63); higher ventilatory reserve (VR) (IS: 93,3+/-23,3ml/min; CH: 78,8+/-18,3ml/min, p=0,024) signficant diferent comparing to control group (all p<0,0001). There was correlation between VO2 peak and VE (IS: r=0,48, p=0,006; CH: r=0,49, p=0,008); and a inverse correlation between aerobic condition and ventilatory reserve (IS: r=-0,49, p=0,005; CH: r=-0,58, p=0,001).Conclusions: In patients with advanced HF, IS or CH etiology, EC was inversely related to VR. Exercise breathlessness seems to be related to inefficiency using of VR. This reinforces the importance of specific respiratory muscles training in HF.