PT - JOURNAL ARTICLE AU - Celina Schlaack AU - Michael Neurath AU - Martha Dlugaj AU - Daniel Jokisch AU - Gerhard Weinreich AU - Martina Föhring AU - Markus Kamler AU - Helmut Teschler AU - Urte Sommerwerck TI - The influence of different immunosuppressive regimen on non-mnestic cognitive functions in patients after lung transplantation DP - 2014 Sep 01 TA - European Respiratory Journal PG - P266 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P266.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P266.full SO - Eur Respir J2014 Sep 01; 44 AB - Background:Cognitive impairment in patients after lung transplantation seems to be associated with different immunosuppressive drugs. The aim of the present study was to examine non-mnestic cognitive functions in patients on calcineurininhibitor (CNI: Cyclosporin-CSA or Tacrolimus-TAC) and mTor-inhibitor (mTor-I) Sirolimus in a cross-sectional study.Methods and patients:We included 97 patients (mean age 54±9.2; 53 men) after lung transplantation (5.2±3.7 years post-transplant), 77 on CNI (TAC n=50, CSA n=27) and 20 on mTor-I (Sirolimus). A detailed neuropsychological examination was conducted using standardized measures to assess non-mnestic cognitive functions like attention (d2 test, TMT A), executive functions (TMT B, a verbal fluency test) and motor performance (Grooved Pegboard Test). Group comparisons of administered drugs (mTor-I vs. CNI (n=77)) and time after lung transplantation in the CNI group (<1 year (n=12) vs. >5 years (n=38)) were used to compare performance in cognitive functioning.Results:Patients on mTor-I showed significantly better performance regarding attention in comparison to CNI-patients (p=.036). In the CNI group, patients who were transplanted <1year performed better regarding several attention measures in comparison to patients transplanted >5years ago. We did not find any significant differences in other cognitive functions.Conclusions:The intake of CNI has a negative influence on attention processes in comparison to the intake of mTor-I. The longitudinal follow-up of our patients will allow us to examine the association of intraindividual changes in attention with the duration of different immunosuppressive drug intake.